Unit 1TRICKS Krebs / TCA Cycle
CIA sends soldiers from Michigan/Ontario
Can I Keep Selling Sex For Money, Officer?
C-citrate, I-isocitrate, A-alph KG, S-succinyl COA, S-succinate, F-fumarate, M-malate, 5O-oxaloacetate
Urea cycle intermediates:
Ordinarily, Crappers Are Also Frivolous About Urination
Cindy Always Aches For An Unprotected Orgasm
Cindy (carbomoyl phospate) Called (citrulline) And (aspartate) Asked (arginosuccinate) For (fumarate) An (arginine) Unprotected (urea) Orgasm (ornithine)
Ornithine, Citrulline, Aspartate (enters the cycle), Argininosuccinate, Fumarate (leaves the cycle), Arginine, Urea (leaves the cycle)
Metabolism
Fatty acids 12-20 carbons long, SATURATED: LaMPSA
Laura, My Pal Stares at your Arse (ONLY EVENS)
Lauric, Myristic, Palmitic, Stearic, Arachidic
Let's Try Making Prostitutes Parade in the Medieval Section of the National Archives (ALL)
Lauric, Tridecylic, Myristic, Pentadecylic, Palmitic, Margaric, Stearic, Nonadecylic, Arachidonic
Ketogenic Amino Acids
In addition to phenylalanine (F) and tyrosine (Y), a KWILT keeps you warm when you're starving
FLY, KWILT
Lysine-K, Twptophan-W, Isoleucine-I, Leucine-L, Threonine-T can be converted into Acetyl CoA
WTFYKIL (wtf why kill?)
OR:
Acetyl-CoA <== Leucine, Threonine, Isoleucine, Tryptophan, Lysine
Act Like THis ISn't Too Lame.
Acetoacetate <== Phenylalanine, Leucine, Tyrosine
AArdvarks PHucking Love Texas
Glucogenic Amino Acids
Pyruvate <== Tryptophan, Threonine, Isoleucine, Leucine
Please, Take These Into Lecture.
Alpha-Ketoglutarate <== Glutamate, Arginine, Histidine, Glutamine, Proline
All Glamorous And Hot Girls Party
Succinyl-CoA <== Methionine, Threonine, Isoleucine, Valine
South Carolina Makes (Strom) THurmond Irritatingly Virile
Fumarate <== Aspartate, Threonine, Phenylalanine
Fuck All These Phacts
Oxaloacetate <== Aspartate, Asparagine
OxAloAcetate
Enzymes
kmpitative inhibitor == km increase ,vmax same
non kmpitative inhibitor == km not increased, vmax decreased
UNcompetitive inhibitors are UNfair because they kill both players, Km and Vmax
Carboxylases need ABC:
ATP, Biotin, CO2
All Dehydrogenases: make NADH
All Kinases: Phosphorylate (KINdly put a phosphate on)
All Phosphatases: DEphosphorylate (PhosphaTASE, TAKES off Phosphate)
Glucagon puts Phosphate ON (phosphorylates); and INversely INsulin does the opposite (dephosphorylate)
This is a good way to remember what enzymes of which pathways are active/inactive in
phosphorylated/dephosphorylated form eg. Insulin activates Glycolysis, and Glycogen synthesis, so the enzymes that it activates in those pathways will be active in DEphosphorylated form.
and: Glucagon activates Glycogenolysis and Gluconeogenesis, so the enzymes that it activates in those pathways will be active in Phosphorylated form.
DNA Translation/Transcription/Replication/etc.
Lagging strand- dna polymerase Delta (just memorize, or lowercase a kinda looks like a delta)
LEading strand – dna pol Epsilon
LeAding strand/LAgging strand- dna polymerase Alpha
Cell Cycle
Prophase, Prometaphase, Metaphase, Anaphase, Telophase, Cytokinesis
Prostitutes Periodically Meet And Take Clients
Other Stuff
CO binds CO (carbon monoxide binds cytochrome oxidase)
Use both hands to HUG (pathways that take place in both cytoplasm and mitochondria):
Heme synthesis, Urea cycle, Gluconeogenesis
Shuttles related to lipids
SIT and synthesize...CITRATE -->synthesis
CAR burns Fuel ....CARnitine --> burning fat
If I could be an enzyme, I'd be DNA helicase so I could unzip your genes. SITES Mnemonics from the M1 class: https://docs.google.com/Doc?docid=0AaUOu77obkI6ZDR4Njc5el8zMWR6aG45bWR3&hl=en Concept Map of metabolism: http://www.healthbuilding.com/images/metabolic-concept-map.jpg Mitochondrial protein transport of nuclear proteins explanation: Link Protein synthesis, a 1970's epic on the cellular level from Stanford: http://www.youtube.com/watch?v=u9dhO0iCLww MedStudySites.com: http://www.medstudysites.com/ The MedSpot: http://medspot.googlepages.com/home2 Biochem Animations: http://www.wiley.com/legacy/college/boyer/0470003790/animations/animations.htm Lehninger, Nelson and Cox, Principles of Biochemistry 3-e: http://www.worthpublishers.com/lehninger/ Medical Genetics: http://medgen.genetics.utah.edu/ CHUCK NORRISMs Chuck Norris doesn't believe in maternal inheritance. All his mitochondria are passed to his children. Chuck Norris doesn't need clathrins, small GTPases, tethering complexes, or SNAREs. His vesicles bud off out of fear and are powered by his sheer rage. Chuck Norris gets A's in a pass fail curriculum. Chuck Norris doesn't need a proton gradient. He roundhouses his ATP synthase into action. Chuck Norris doesn't need caspases. He delivers cell death through his roundhouse. Chuck Norris's tears can cure cancer. Too bad he's never cried. All of Chuck Norris' genes are homozygous dominant. 
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